Evidence of Work:
This project was all about protein caused diseases. It was really interesting learning about Huntington's disease and how protein synthesis/folding works. We first had to choose a disease that was caused my a mutation of some protein. We researched the disease to have all the information create our final project. We made a poster describing Huntington's disease and how protein synthesis/folding works.
This project was all about protein caused diseases. It was really interesting learning about Huntington's disease and how protein synthesis/folding works. We first had to choose a disease that was caused my a mutation of some protein. We researched the disease to have all the information create our final project. We made a poster describing Huntington's disease and how protein synthesis/folding works.
Content:
Protein Synthesis
1. Transcription
- Starts in the nucleus of the cell. The DNA is split apart and RNA polymearse adds nucleotides to the other side of it to create mRNA or the code for making a protein. The mRNA then leaves the nucleus and heads to the cytoplasm to find a ribosome.
- The mRNA attaches to a ribosome in the cytoplasm. The ribosome reads the mRNA each codon or three letters at a time. Then the tRNA brings the anti codon with the correct amino acid that matches. The amino acids that are brought to the ribosome attach and create a polypeptide chain. The chain then folds creating a working protein.
Anti codon- The opposite sequence that matches the three letter codon.
Amino Acids- The basic building blocks of a protein. They make up a lot of our body and they carry out important jobs that are needed for us to survive.
Polymerase- An enzyme that is used to create mRNA. It adds nucleotide to complete DNA in transcription.
Polypeptide Chain- A chain of amino acids connected together to create a protein.
Proteins- makes up important parts of the body like muscles and hair. Made from a polypeptide chain.
Transcription- The first step of protein synthesis that occurs in the nucleus and creates mRNA.
Translation- The second step of protein synthesis that makes a polypeptide chain.
Protein Folding
Primary Structure- The polypeptide chain is the first stage of protein folding. This occurs in the cytoplasm after going through translation.
Secondary Structure- The second stage is when the chain starts folding into two structures. This occurs in the rough endoplasmic reticulum (ER).
- Alpha helix is when the polypeptide chain folds into a helix like DNA
- Beta sheets is when the chain just folds over itself
Quaternary Structure- The last stage is when multiple of the unfinished structures come together to make a working protein in the golgi body.
RNA
mRNA- Stands for messenger RNA. It conveys DNA information to the ribosome to eventually make the correct protein.
tRNA- Stands for transfer RNA. It brings the right amino acids to the ribosome to make the correct polypeptide chain.
Reflection:
This project was really fun and I think my group worked well together but there is a few things we can still improve on. We did a good job at splitting the work so it was more efficient. We each researched different questions that had to be answered and we also did different parts of the poster. We did a good job of communication because we all knew what we were supposed to do to complete the project. We knew what questions we were answering and what we needed to get done. Next time to make our project better we might need to spend a little more time on the actual finished product. We took a lot of the time to research when we already had the necessary information. Another thing we could have done better was being more on top of our work. Some of the time we would start doing another thing that didn't relate to the project. Other than that this project went really well and it was easy to work with my group. I am going to try and improve some things for the next project to make it even better.